Dietary fatty acids affect mitochondrial phospholipid compositions and mitochondrial gene expression of rainbow trout liver at different ages.

Mitochondria are among the first responders to various stressors that challenge the homeostasis of cells and organisms. Mitochondrial decay is generally associated with impairment in the organelle bioenergetics function and increased oxidative stress, and it appears that deterioration of mitochondrial inner membrane phospholipids (PL), particularly cardiolipin (CL), and accumulation of mitochondrial DNA (mtDNA) mutations are among the main mechanisms involved in this process. In the present study, liver mitochondrial membrane PL compositions, lipid peroxidation, and mtDNA gene expression were analyzed in rainbow trout fed three diets with the same base formulation but with lipid supplied either by fish oil (FO), rapeseed oil (RO), or high DHA oil (DHA) during 6 weeks. Specifically, two feeding trials were performed using fish from the same population of two ages (1 and 3 years), and PL class compositions of liver mitochondria, fatty acid composition of individual PL classes, TBARS content, and mtDNA expression were determined. Dietary fatty acid composition strongly affected mitochondrial membrane composition from trout liver but observed changes did not fully reflect the diet, particularly when it contained high DHA. The changes were PL specific, CL being particularly resistant to changes in DHA. Some significant differences observed in expression of mtDNA with diet may suggest long-term dietary effects in mitochondrial gene expression which could affect electron transport chain function. All the changes were influenced by fish age, which could be related to the different growth rates observed between 1- and 3-year-old trout but that could also indicate age-related changes in the ability to maintain structural homeostasis of mitochondrial membranes.

Tumor mixto de glándulas salivales [adenoma pleomorfo] en el septum nasal / Mixed tumor of salivary glands [pleomorphous adenoma] in the nasal septum

La cavidad nasal es un área relativamente infrecuente como punto de origen de tumores: en ésta se localizan cerca del 10 por ciento de las neoplasias de glándulas salivales menores, siendo una de sus variedades el adenoma pleomorfo o tumor mixto. El diagnóstico y tratamiento de esta patología se dificulta por su presentación poco usual , su variado comportamiento biológico, y la dificultad en su manejo por el posible compromiso de estructuras vecinas. Se presenta el caso de una mujer de 37 años de edad, con un cuadro clínico consistente en cefalea, rinorrea verdosa, obstrucción nasal derecha y presencia de masa a nivel de la porción anterosuperior del septum nasal, con diagnóstico anatomopatológico de adenoma pleomorfo